{"id":15266,"date":"2021-05-05T20:28:55","date_gmt":"2021-05-05T20:28:55","guid":{"rendered":"http:\/\/avrupapress.com\/main\/?p=15266"},"modified":"2021-05-05T20:29:10","modified_gmt":"2021-05-05T20:29:10","slug":"corona-virusun-tum-mutasyonlarini-etkisiz-hale-getirebilen-antikor-ilaci-insan-denemelerine-basladi-ly-cov1404","status":"publish","type":"post","link":"https:\/\/avrupapress.com\/main\/2021\/05\/05\/corona-virusun-tum-mutasyonlarini-etkisiz-hale-getirebilen-antikor-ilaci-insan-denemelerine-basladi-ly-cov1404\/","title":{"rendered":"Corona vir\u00fcs\u00fcn t\u00fcm mutasyonlar\u0131n\u0131 etkisiz hale getirebilen antikor ilac\u0131 insan denemelerine ba\u015flad\u0131: LY-CoV1404"},"content":{"rendered":"

Eli Lilly ve AbCellera taraf\u0131ndan yeni tip corona vir\u00fcse (Covid-19) kar\u015f\u0131 geli\u015ftirilen bir antikor ilac\u0131n\u0131n \u0130ngiltere, Brezilya, California ve G\u00fcney Afrika\u2019da tan\u0131mlananlar da dahil olmak \u00fczere \u00e7ok say\u0131da corona vir\u00fcs mutasyonunu \u00ab\u00a0g\u00fc\u00e7l\u00fc bir \u015fekilde\u00a0\u00bb etkisiz hale getirdi\u011fi a\u00e7\u0131kland\u0131. \u015eirketler, \u00ab\u00a0LY-CoV1404\u00a0\u00bb adl\u0131 monoklonal antikor tedavisinin, corona vir\u00fcs\u00fcn mutasyona u\u011frayan \u00e7ok say\u0131da k\u0131sm\u0131na ba\u011flanarak \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131, yani ilac\u0131n zaman i\u00e7inde etkinli\u011fini koruyabilece\u011fini duyurdu. \u015eu anda insan denemelerine ba\u015flayan ila\u00e7 e\u011fer ba\u015far\u0131l\u0131 sonu\u00e7lar g\u00f6sterirse, pandemiye kar\u015f\u0131 bir oyun de\u011fi\u015ftirici olacak ve uzun vadede mutasyon endi\u015fesini ortadan kald\u0131racak.<\/h2>\n
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\"Corona<\/picture><\/div>\n
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Kanadal\u0131 AbCellera ve ABD\u2019li Eli Lilly Covid-19\u2019a kar\u015f\u0131 birlikte geli\u015ftirdikleri ikinci bir antikor ilac\u0131n\u0131n klinik denemelerine ba\u015flad\u0131klar\u0131n\u0131 a\u00e7\u0131klad\u0131. \u0130la\u00e7 \u015firketleri, LY-CoV1404 ad\u0131 verilen monoklonal antikor tedavisini\u00a0 hafif ile\u00a0 orta derecede Covid-19 hastalar\u0131nda de\u011ferlendirece\u011fini duyurdu.<\/p>\n<\/div>\n<\/div>\n

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\"Corona<\/picture><\/div>\n
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T\u00dcM MUTASYONLARA KAR\u015eI G\u00dc\u00c7L\u00dc ETK\u0130 G\u00d6STERD\u0130<\/h2>\n

Bununla birlikte, AbCellera\u00a0 LY-CoV1404\u2019\u00fcn kilinik \u00f6ncesi denemelerinde corona vir\u00fcs\u00fcn\u00a0 bilinen t\u00fcm mutasyonlar\u0131na kar\u015f\u0131 g\u00fc\u00e7l\u00fc etki g\u00f6sterdi\u011fi belirtildi.<\/p>\n<\/div>\n<\/div>\n

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\"Corona<\/picture><\/div>\n
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AbCellera, antikor ilac\u0131n\u0131n \u0130ngiltere, Brezilya, California, G\u00fcney Afrika ve New York mutasyonlar\u0131 da dahil olmak \u00fczere corona vir\u00fcs\u00fcn \u015fu anda bilinen t\u00fcm varyantlar\u0131n\u0131 n\u00f6tralize etti\u011fini ve ilac\u0131n corona vir\u00fcs\u00fcn ba\u015fak proteininin mutasyona u\u011frayan b\u00f6lgesine ba\u011fland\u0131\u011f\u0131n\u0131 duyurdu.<\/p>\n<\/div>\n<\/div>\n

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\"Corona<\/picture><\/div>\n
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BA\u015eAK PROTE\u0130N\u0130N MUTASYONA U\u011eRAYAN B\u0130RKA\u00c7 YER\u0130NE BA\u011eLANIYOR<\/h2>\n

Ba\u015fak protein corona vir\u00fcs\u00fcn insanlar\u0131n ACE2 enzimlerine tutunarak v\u00fccuda girmesine ve hastal\u0131\u011fa yol a\u00e7\u0131yor. Ara\u015ft\u0131rmac\u0131lar vir\u00fcs\u00fcn bu b\u00f6lgesinde mutasyonlarla gelen de\u011fi\u015fikliklerin endi\u015fe verici oldu\u011funu d\u00fc\u015f\u00fcn\u00fcyor, \u00e7\u00fcnk\u00fc a\u015f\u0131lar da vir\u00fcs\u00fcn ba\u015fak proteinin hedef al\u0131yor.<\/p>\n<\/div>\n<\/div>\n

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\"Corona<\/picture><\/div>\n
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PANDEM\u0130DEK\u0130 MUTASYON TEHD\u0130D\u0130N\u0130 ORTADAN KALDIRAB\u0130L\u0130R<\/h2>\n

Ancak, AbCallere geli\u015ftirilen antikor ilac\u0131n\u0131n ba\u015fak proteinin bir\u00e7ok k\u0131sm\u0131na ba\u011flanabildi\u011fini bu nedenle ilac\u0131n etkisini olas\u0131 yeni mutasyonlar nedeniyle yitirmeyece\u011fini s\u00f6yledi. Klinik testlerin son a\u015famas\u0131nda bu durum kan\u0131tlan\u0131rsa\u00a0 LY-CoV1404\u2019\u00fcn corona vir\u00fcs tedavisinde oyun de\u011fi\u015ftirici olabilece\u011fi ifade edilerek, varyantlar\u0131n yaratt\u0131\u011f\u0131 tehdidi ortadan kald\u0131rabilece\u011fi ifade edildi.<\/p>\n


\n<\/strong><\/p>\n<\/div>\n<\/div>\n

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\"Corona<\/picture><\/div>\n
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Bununla birlikte, LY-CoV1404, iyile\u015fen bir Covid-19\u00a0 hastas\u0131ndan al\u0131nan bir kan \u00f6rne\u011finden geli\u015ftirildi. Antikor, corona vir\u00fcs\u00fc sivri glikoprotein resept\u00f6r ba\u011flanma alan\u0131 (RBD) \u00fczerinde y\u00fcksek oranda korunmu\u015f bir epitopu hedefleyerek ACE2’ye viral ba\u011flanmay\u0131 bloke ederek \u00e7al\u0131\u015f\u0131yor. AbCellera bu etkiyi,\u00a0 \u00ab\u00a0g\u00fc\u00e7l\u00fc n\u00f6trle\u015ftirme aktivitesi i\u00e7in iyi belgelenmi\u015f bir mekanizma\u00a0\u00bb olarak tan\u0131mlad\u0131.<\/p>\n


\n<\/strong><\/p>\n<\/div>\n<\/div>\n

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\"Corona<\/picture><\/div>\n
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AbCellera\u2019n\u0131n CEO\u2019su Carl Hansen, \u201cLY-CoV1404 analizimiz, onun son derece g\u00fc\u00e7l\u00fc oldu\u011funu ve \u015fu anda bilinen t\u00fcm mutasyonlar\u0131 etkisiz hale getirdi\u011fini g\u00f6steriyor. LY-CoV1404’\u00fcn, Covid-19\u2019un endemik hale gelmesi durumunda a\u015f\u0131lara uzun vadeli bir tamamlay\u0131c\u0131 sa\u011flama potansiyeli bizi cesaretlendiriyor. LY-CoV1404, Covid-19 antikor tedavilerini h\u0131zla geli\u015ftirme, test etme ve k\u00fcresel olarak tedarik etmede lider olan orta\u011f\u0131m\u0131z ile birlikte , devam eden BLAZE-4 denemesinin bir par\u00e7as\u0131 olarak geli\u015ftirdik\u00a0\u00bb dedi.<\/p>\n<\/div>\n<\/div>\n

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\"Corona<\/picture><\/div>\n
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TEK BA\u015eINA YA DA D\u0130\u011eER ANT\u0130KOR TEDAV\u0130LER\u0130YLE B\u0130RL\u0130KTE KULLANILAB\u0130L\u0130R<\/h2>\n

Ek olarak, LY-CoV1404\u2019\u00fcn\u00a0 di\u011fer geni\u015f \u00f6l\u00e7\u00fcde n\u00f6tralize edici antikorlara k\u0131yasla viral n\u00f6tralizasyon deneylerinde \u00f6nemli \u00f6l\u00e7\u00fcde daha g\u00fc\u00e7l\u00fc oldu\u011fu g\u00f6r\u00fcld\u00fc. Bu nedenle ilac\u0131n tek ba\u015f\u0131na\u00a0 veya viral varyantlar\u0131n y\u00fckselmesi nedeniyle etesevimab iya da ABD\u2019de \u00f6nceden onaylanan\u00a0 bamlanivimab da dahil olmak \u00fczere\u00a0 di\u011fer antikorlarla kombinasyon halinde kullan\u0131labilece\u011fi a\u00e7\u0131kland\u0131.<\/p>\n<\/div>\n<\/div>\n

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\"Corona<\/picture><\/div>\n
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Di\u011fer taraftan, Eli Lilly ayr\u0131ca Vir Biotechnology ve GlaxoSmithKline taraf\u0131ndan geli\u015ftirilen bir monoklonal antikor ile kombinasyon halinde bamlanivimab’\u0131 de\u011ferlendiriyor. VIR-7831 adl\u0131 ila\u00e7\u00a0 hafif ila orta derecede Covid-19’u olan d\u00fc\u015f\u00fck riskli hastalarda bamlanivimab ile kombinasyon halinde inceleniyor.<\/p>\n<\/div>\n<\/div>\n

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\"Corona<\/picture><\/div>\n
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ABCELLERA TES\u0130SLER\u0130N\u0130 B\u00dcY\u00dcT\u00dcYOR<\/h2>\n

\u00d6te yandan, Covid-19 ve di\u011fer viral tehditlere kar\u015f\u0131 devam eden \u00e7abalar\u0131n\u0131 desteklemek i\u00e7in AbCellera, k\u0131sa s\u00fcre \u00f6nce Vancouver’daki merkezini geni\u015fletmek i\u00e7in temel att\u0131. Projenin, \u00f6n\u00fcm\u00fczdeki birka\u00e7 y\u0131l i\u00e7inde mevcut 250 ki\u015filik i\u015fg\u00fcc\u00fcne y\u00fczlerce \u00e7al\u0131\u015fan\u0131 ekleyerek \u015firketin \u00f6nemli \u00f6l\u00e7\u00fcde b\u00fcy\u00fcmesine olanak sa\u011flamas\u0131 bekleniyor.<\/p>\n

Geni\u015flemenin toplam 115 bin metrakelik iki tesisi kapsamas\u0131 ve bu tesislerin 2023 ve 2024 y\u0131llar\u0131nda tamamlanmas\u0131 hedefleniyor.<\/p>\n

Hansen, yapt\u0131\u011f\u0131 a\u00e7\u0131klamada, \u00ab\u00a0D\u00fcnyan\u0131n d\u00f6rt bir yan\u0131ndan biyoteknoloji ve ila\u00e7 ortaklar\u0131yla yeni antikor tedavilerinin geli\u015ftirilmesini h\u0131zland\u0131rmak i\u00e7in Vancouver’da son teknoloji tesisler in\u015fa ediyoruz. Bu teknoloji kamp\u00fcs\u00fcn\u00fcn, yetenekli insanlar\u0131n her yerdeki hastalar\u0131n yarar\u0131na antikor ke\u015ffini \u00f6nemli \u00f6l\u00e7\u00fcde iyile\u015ftirmeye ve h\u0131zland\u0131rmaya katk\u0131da bulunabilece\u011fi bir yer olarak hizmet vermeyi ama\u00e7l\u0131yoruz\u00a0\u00bb ifadelerini kulland\u0131.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Eli Lilly ve AbCellera taraf\u0131ndan yeni tip corona vir\u00fcse (Covid-19) kar\u015f\u0131 geli\u015ftirilen bir antikor ilac\u0131n\u0131n \u0130ngiltere, Brezilya, California ve G\u00fcney Afrika\u2019da tan\u0131mlananlar da dahil olmak \u00fczere \u00e7ok say\u0131da corona vir\u00fcs mutasyonunu \u00ab\u00a0g\u00fc\u00e7l\u00fc bir \u015fekilde\u00a0\u00bb etkisiz hale getirdi\u011fi a\u00e7\u0131kland\u0131. \u015eirketler, \u00ab\u00a0LY-CoV1404\u00a0\u00bb adl\u0131 monoklonal antikor tedavisinin, corona vir\u00fcs\u00fcn mutasyona u\u011frayan \u00e7ok say\u0131da k\u0131sm\u0131na ba\u011flanarak \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131, yani ilac\u0131n […]<\/p>\n","protected":false},"author":3,"featured_media":15267,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,16,3,19,2],"tags":[6796,6794,6797,6795],"class_list":["post-15266","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-avrupa","category-belcika","category-dunya","category-tanitim","category-turkiye","tag-antikor-ilaci","tag-corona-virusun","tag-insan-denemelerine-basladi-ly-cov1404","tag-tum-mutasyonlarini-etkisiz-hale-getirebilen"],"yoast_head":"\nCorona vir\u00fcs\u00fcn t\u00fcm mutasyonlar\u0131n\u0131 etkisiz hale getirebilen antikor ilac\u0131 insan denemelerine ba\u015flad\u0131: LY-CoV1404 - 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